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SoftWave Research

Newest Research

Click to access Science Compendium List 2024_02_02
European Heart Journal
Sticky Post

SoftWave TRT Affiliate Study Featured in Prominent Medical Journal

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Extracorporal SoftWave Treatment to Improve Nerve Regeneration

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Shock wave treatment reduces neuronal degeneration upon spinal cord ischemia and improves symptomes in a first-in-man trial

Stem cells pose risk, offer promise

Extracorporeal shock waves, a new non-surgical method to treat severe burns

Efficacy of Extracorporeal Shockwave Therapy on Pain and Function in Myofascial Pain Syndrome of the Trapezius: A Systematic Review and Meta-Analysis

Comparing Shockwave Technologies for Treating Diabetic Foot Ulcers

Best Medical Devices for Treating ACL Injuries 

Best Medical Devices for Treating ACL Injuries 

Plantar Fasciitis Medical Devices That Relieve Pain

Does Dermapace Work for Patients?

Sound Frequency Healing: The Spark of Life

The Role of Extracorporeal Shockwave Treatment in Musculoskeletal Disorders

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A study to identify the potential effects of extracorporeal shockwave therapy alone and in combination with Avastin.

Effect of a Single Administration of Focused Extracorporeal Shock Wave in the Relief of Delayed-Onset Muscle Soreness: Results of a Partially Blinded Randomized Controlled Trial

Prospective Randomized Trial of Accelerated Re-Epithelization of Skin Graft Donor Sites Using Extracorporeal Shock Wave Therapy

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Regenerative Treatments for Athletes and Their Role Compared With Surgical Repair

Regenerative Treatments for Athletes Versus Surgical Repair

Shockwave Therapy: Does it Hurt?

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Why SoftWave Is the Proven Standard in Regenerative Medicine Devices

Why SoftWave Is the Proven Standard in Regenerative Medicine Devices

Molecular and Cellular Effects of In Vitro Shockwave Treatment on Lymphatic Endothelial Cells

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Novel Approach to Obtain an Activated Fat Graph

Knee Pain Relief through Advanced Shockwave Therapy

SoftWave: Leading the Way in Knee Pain Relief through Advanced Shockwave Therapy

The Role of the Low-Intensity Extracorporeal Shockwave Therapy on Penile Rehabilitation After Radical Prostatectomy: A Randomized Clinical Trial

Elucidating the molecular mechanisms underlying cardiac shock wave therapy

Pulsewave Therapy- Mechanism of Action and Clinical Indications

Pulsewave Therapy Explained: Mechanism of Action and Clinical Indications

Effects of Extracorporeal Shock Wave Therapy on Spasticity in Patients after Brain Injury: A Meta-analysis

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OmniWave Shockwave Machines: Efficacy & Alternatives Explained

Biological Principles – Mechanotransduction

Focused high‐energy extracorporeal shockwaves as supplemental treatment in a rabbit model of fracture‐related infection

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Alternatives to Surgery

Case Series of Weekly Low Intensity Shock Wave Therapy for Erectile Dysfunction

The Clinician’s Guide to Shockwave Therapy- Evidence, Safety, and Technology

The Clinician’s Guide to Shockwave Therapy: Evidence, Safety, and Technology

Extracorporeal shock wave therapy for calcifying tendinitis of the shoulder

Impact of extracorporeal shock-wave therapy on the stability of temporary anchorage devices in adults: A single-center, randomized, placebo-controlled clinical trial

Dermapace Machines- Cost, Efficacy, & Alternatives

Dermapace Machines: Cost, Efficacy, & Alternatives

Shock Wave Therapy Improves Cardiac Function in a Model of Chronic Ischemic Heart Failure: Evidence for a Mechanism Involving VEGF Signaling and the Extracellular Matrix

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Alternative Treatment using Shockwave for Erectile Dysfunction

Morton's Neuroma

Effective Medical Devices for Treating Morton’s Neuroma

Low-Intensity Extracorporeal Shock Wave Therapy Enhances Brain-Derived Neurotrophic Factor Expression through PERK/ATF4 Signaling Pathway

Immunomodulation of Osseointegration Through Extracorporeal Shock Wave Therapy

New Treatment Option for Clinical and Subclinical Mastitis in Dairy Cows Using Acoustic Pulse Technology (APT)

Cellulite and focused extracorporeal shockwave therapy for non-invasive body contouring: a randomized trial.

Alternatives to Back Surgery Doctors Should Consider

Alternatives to Back Surgery Doctors Should Consider

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Fully healed, Ordonez flourished for Tigers using ESWT

Extracorporeal shock wave promotes growth and differentiation of bone-marrow stromal cells towards osteoprogenitors associated with induction of TGF-β1

Extracorporeal shock wave therapy effectively prevented diabetic neuropathy

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​Low-energy shock wave for enhancing recruitment of endothelial progenitor cells: a new modality to increase efficacy of cell therapy in chronic hind limb ischemia

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ESWT for retracting scars of the hand

Shock waves promote spinal cord repair via TLR32

Hip Pain Management with Advanced Shockwave Therapy

SoftWave: Revolutionizing Hip Pain Management with Advanced Shockwave Therapy

Impact of extracorporeal shock wave therapy (ESWT) on orthodontic tooth movement—a randomized clinical trial​

Placebo controlled, prospectively randomized, double-blinded study for the investigation of the effectiveness and safety of the acoustic wave therapy (AWT(®)) for cellulite treatment.

Effects of the extracorporeal shock wave therapy on the skin: an experimental study

Shock wave therapy compared with intramedullary screw fixation for nonunion of proximal fifth metatarsal metaphyseal-diaphyseal fractures

Review of the Current Status of Low Intensity Extracorporeal Shockwave Therapy (Li-ESWT) in Erectile Dysfunction (ED)

Alteration Of Inflammatory Response By Shock Wave Therapy Leads To Reduced Calcification Of Decellularized Aortic Xenografts In Mice.

Effect of Low-energy Extracorporeal Shock Waves on Orthodontic Tooth Movement and Miniscrew Stability

SoftWave OrthoGold

Best Medical Devices for Treating Wrist Tendonitis 

​Update on the efficacy of extracorporeal shockwave treatment for myofascial pain syndrome and fibromyalgia

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Extrakoprorale Stoßwellentherapie am Knochen – Voodoo oder Therapieoption?

Radial Shockwave Therapy Machines Compared 

Veterinary wound care case study

Shockwave Therapy for Calcific Tendonitis

Alternatives to Cortisone Shots for Joint Pain Relief

Alternatives to Cortisone Shots for Joint Pain Relief

Extracorporeal Shock Wave Therapy for Treatment of Vulvodynia: A prospective, randomized, double-blind, placebo-controlled study

Cardiovascular Implications of Fatal Outcomes of Patients With Coronavirus Disease 2019 (COVID-19)

Tissue Activation and Regeneration in Sports Medicine and Bone Pathologies

Shock wave therapy causes increased macrophage recruitment and enhances M2 polarization

Effectiveness of extracorporeal shock wave for low back pain (A protocol of systematic review)

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Low Intensity Shock Wave Therapy: Regenerative Therapy for Erectile Dysfunction

MTS Spark Wave Publications – Science Telegram

Shockwave Therapy Contraindications- When Not to Use It

Shockwave Therapy Contraindications: When Not to Use It

A First Prospective, Randomized, Double-Blind, Placebo-Controlled Clinical Trial Evaluating Extracorporeal Shock Wave Therapy for the Treatment of Peyronie ’s Disease

Zapping chronic tendon pain

Heart Regeneration becomes Reality!

Macrophage migration induces angiogenesis

DolorClast Therapy- Mechanism, Indications, and Clinical Evidence

DolorClast Therapy: What Is It & Does It Work for Patients?

Shockwave Therapy for Plantar Fasciitis

Shock Waves Reach Dental Implantology (Spanish)

Low-energy shock waves treatment induces angiogenesis in ischemic muscle by stimulation of Toll-like receptor 3 signalling

Original hypothesis: Extracorporeal shockwaves as a homeostatic autoimmune restorative treatment (HART) for Type 1 diabetes mellitus

SoftWave Therapy Averts Amputation for Former College Football Coach

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Impact of Extracorporeal Shockwave Therapy on Tooth Mobility in Adult Orthodontic Patients: A Randomized Single-Center Placebo-Controlled Clinical Trial

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Efficacy and safety of extracorporeal shock wave therapy for acute and chronic soft tissue wounds: A systematic review and meta-analysis

​STORZ MEDICAL’s NEUROLITH® receives CE approval – Transcranial Pulse Stimulation (TPS) on the central nervous system of patients with Alzheimer’s disease

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How Shockwave Therapy Breaks Down Scar Tissue

Renova Shockwave Therapy- What Is It & Does It Work for Patients?

Renova Shockwave Therapy: What Is It & Does It Work for Patients?

Piezowave Shockwave Therapy vs Other Shockwave Devices

Piezowave Shockwave Therapy vs Other Shockwave Devices

Acoustic stimulation and tropism on skeletal muscles: Tissue resilience & regeneration in sports and aging

Effectiveness of shock wave therapy: implementation of a soft wide focus applicator in patients with erectile dysfunction

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What Doctors Should Know About Storz Medical Shockwave

Alteration of inflammatory response by shock wave therapy leads to reduced calcification of decellularized aortic xenografts in mice

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The Assessment of New Bone Formation Induced by Unfocused Extracorporeal Shock Wave Therapy Applied on Pre-Surgical Phase of Distraction Osteogenesis

The efficacy of ultrasound-guided extracorporeal shockwave therapy in patients with cervical spondylosis and nuchal ligament calcification

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What Is HydroWave Therapy? Mechanism, Applications, and Clinical Context

What Is HydroWave Therapy? How It Works, Clinical Uses, and Evidence

Shock wave treatment reduces neuronal degeneration upon spinal cord ischemia vi a Toll-like receptor 3 dependent mechanism

Indications for shockwaves in veterinary medicine

Extracorporeal shockwave: mechanisms of action and physiological aspects…

​Role of extracorporeal shock wave therapy in management of Peyronie’s disease: A preliminary report

SoftWave Celebrates Pro Success of Golfer Jake Peacock and Baseball Player Reid Worley, Highlighting Injury Prevention Breakthroughs

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Exploring Alternatives to Pain Treatment: Your Path to Natural Relief

Is it possible to change of the duration of consolidation period in the distraction osteogenesis with the repetition of extracorporeal shock waves

Project: SoftWaves to prevent opioid addiction and to help addicts in their recovery.

Integrating Regenerative Treatments for Ankle Pain in Active Patients

Integrating Regenerative Treatments for Ankle Pain in Active Patients

Is it possible to change of the duration of consolidation period in the distraction osteogenesis with the repetition of extracorporeal shock waves?

SoftWave TRT vs Storz Shockwave Machines Compared

Shockwave Therapy for Muscle Pain and Injuries

Shockwave Therapy for Muscle Pain and Injuries

Efficacy of extracorporeal shock wave therapy (ESWT) for males chronic pelvic pain syndrome

Acoustic Field of a Ballistic Shock Wave Therapy Device

Medispec Shockwave Devices- Efficacy & Alternatives

Medispec Shockwave Devices: Efficacy & Alternatives

Variable Sound -Fields of Electro-Hydraulic Extracorporeal Shockwave Applicators

Relief for Back Pain with Innovative Shockwave Therapy

SoftWave ESWT: Redefining Relief for Back Pain with Innovative Shockwave Therapy

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10 Questions Every Provider Should Ask Before Choosing a Shockwave Medical Device

10 Questions Every Provider Should Ask Before Choosing a Shockwave Medical Device

Exploring Regenerative Treatment for Knees After Failed Conservative Care

Regenerative Treatment for Knees That Fail Conservative Care

What Is Piezowave and How Does It Work?

How Li-ESWT Works for Patients With ED & Other Indications

Ultrasound and shock-wave stimulation to promote axonal regeneration following nerve surgery

Extracorporeal shockwave: mechanisms of action and physiological aspects for cellulite, body shaping, and localized fat—Systematic review

EmFocus Shockwave Therapy- Features, Benefits, and Drawbacks

EmFocus Shockwave Therapy: Features, Benefits, and Drawbacks

Epicardial shock-wave therapy improves ventricular function in a porcine model of ischaemic heart disease.

Zimmer enPuls Shockwave Systems Compared and Explained for Clinical Practice

Zimmer enPuls Shockwave Machines Compared

Extracorporeal shock wave therapy for the treatment of coccydynia: a series of 23 cases

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Expanding Non-Surgical Options in Podiatry Clinics

Defining a Therapeutic Range for Regeneration of Ischemic Myocardium via Shock Waves

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Chronic Tendonitis Treatment When Injections Have Failed

Chronic Tendonitis Treatment When Injections Have Failed

Better lithotripsy on the horizon: an interview with James E. Lingeman, MD.

Shock wave treatment of muscle stem cells – a new implementation for regeneration

Extracorporeal shock-wave therapy reduces progression of knee osteoarthritis in rabbits by reducing nitric oxide level and chondrocyte apoptosis​

Body shaping with acoustic wave therapy AWT(®)/EPAT(®): randomized, controlled study on 14 subjects.

Shock wave therapy for acute and chronic soft tissue wounds: A feasibilty study

Effect of shock waves on macrophages: A possible role in tissue regeneration and remodeling

Comparative SWT Data to Evaluate Competing Technologies in the Treatment of Penile Connective Tissue for Improved Erectile Function

Extracorporeal shockwave therapy (ESWT) First choice treatment of fracture non-unions?

Improvement of adipose tissue-derived cells by low-energy extracorporeal shock wave therapy

Effective Medical Devices for Treating Uterine Fibroids

Effective Medical Devices for Treating Uterine Fibroids

ESWT for resident stress fractures in athletes.

EPAT Therapy Costs for Patients & Practices

Extracorporeal Acoustic Wave Therapy and Multiple Symmetric Lipomatosis

UGA In vitro study: ESWT treatment of platelets causes increased release of growth factors

What Is StemWave Therapy? How It Works, What It Costs & How It Compares

Shockwave Therapy for the Treatment of Cancer

opioids united states

FDA Tightens Opioid Warning Labels: Here’s the Non-Invasive Alternative Changing Pain Care

Extracorporeal Shock Wave Therapy in Peyronie’s Disease: Clinical Efficacy and Safety from a Single-Arm Observational Study

Exploring Regenerative Shoulder Treatment for Rotator Cuff and Overuse Injuries

Regenerative Shoulder Treatment for Rotator Cuff and Overuse Injuries

Shock wave therapy alone has no impact on cancer growth

Low Intensity Shock Wave Treatment for Erectile Dysfunction-How Long Does the Effect Last?

SoftWave vs Shockwave Technology Explained 

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Mechano-transduction effect of shock waves

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​Extracorporeal shock wave therapy in periodontics: A new paradigm

Non‑surgical Regenerative Treatments Integrating with PT

Non‑surgical Regenerative Treatments Integrating with PT

Mesenchymal stem cells: Myths and reality

COVID-19 pneumonia: different respiratory treatment for different phenotypes?

ESWT in skin & aesthetic indications

Storz Duolith Machines- Cost, Efficacy, & Alternatives

Storz Duolith Machines Compared

​Exosomes and Cardiovascular Protection

The influence of comorbidities – ESWT for chronic soft tissue wounds

Stromal Vascular Fraction Combined with Shock Wave for the Treatment of Peyronie’s Disease

Extracorporeal Shockwave Therapy for Arthritis Treatment

Letter regarding non unions in Europe. Dr. Schaden managing Director of the Workman’s Compensation Insurance Organization in Austria

Scientific Reports – Gene transfection by shock waves

Regenerative Skin Treatment for Burns, Scars, and Wounds

Regenerative Skin Treatment for Burns, Scars, and Wounds

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Chattanooga Shockwave Devices Compared- What Clinicians Should Evaluate

Chattanooga Shockwave Therapy Devices Compared

Improved rate of peripheral nerve regeneration induced by extracorporeal shock wave treatment in the rat

Peripheral Nerve Regeneration

Peripheral Nerve Regeneration

Ultrasound Based Brain Stimulation

Softwave application on hand

Healing at the Edge of the World: How Dr. Paul Kratka Brings SoftWave to the South Pacific

Principles of Shock Wave Therapy

ESWT affects Schwann cell phenotype in vitro and in vivo thereby accelerating nerve regeneration

Symptomatic treatment of unresponsive wakefulness syndrome with transcranial focused extracorporeal shock waves

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Shock wave therapy for osteoinduction

SoftWave Therapy® Represents a Valuable Addition in the Treatment of Hard-to-Heal Wounds

The Role of Extracorporeal Shock Wave Therapy and Manual Lymphatic Drainage in Chronic Ulcers Treatment

Do Gymna Shockmaster Machines Work for Patients?

Do Gymna Shockmaster Machines Work for Patients?

Extracorporeal shock wave therapy (ESWT) for the treatment of cellulite e A current metaanalysis​ -(Plastic, Hand and Burn Surgery, University of Schlewig Holstein, Lubeck, Germany​)

Low energy shock wave therapy induces angiogenesis in acute hind-limb ischemia via VEGF receptor 2 phosphorylation

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How Does Shockwave Therapy Work?

Regenerative Treatments in Sports and Orthopedic Medicine for Clinicians in 2025

Regenerative Treatments in Sports and Orthopedic Medicine for Clinicians in 2025

Effect of Extracorporeal Shockwave Therapy (ESWT) on Pulpal Blood Flow After Orthodontic Treatment: A Randomized Clinical Trial

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Extracorporeal Shock Wave Device for Treatment of Chronic Wounds

Extracorporeal shock wave therapy (ESWT) in urology:a systematic review of outcome in Peyronie’s disease, erectile dysfunction and chronic pelvic pain

7 Red Flags That Signal a Risky Shockwave Device

Shockwave Therapy for Physical Therapists

How to Improve Podiatry Practice ROI

How to Improve Podiatry Practice ROI

Shockwave therapy differentially stimulates endothelial cells: implications on the control of inflammation via toll-like receptor 3

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Treatment of stress urinary incontinence

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Shockwave Therapy vs. Ultrasound Therapy

Regenerative Therapies for Hip Pain and Tendinopathy

Regenerative Therapies for Hip Pain and Tendinopathy

Shock wave-pretreated bone marrow cells further improve left ventricular function after myocardial infarction in rabbits

Transcranial Pulse Stimulation with Ultrasound in Alzheimer’s disease

MTS Science White Paper – Softwave – Mesenchymal Stem Cell Therapy

Clinical evidence of SparkWave™ therapy in the treatment of erectile dysfunction

Effect of Electrohydraulic Extracorporeal Shockwave Therapy on the Repair of Bone Defects Grafted with Particulate Allografts

Acoustic Wave Therapy vs Shockwave Therapy

Treatment of cutaneous calcinosis in CREST syndrome by extracorporeal shockwave lithotripsy

​Prospective randomized phase II trial of accelerated reepithelialization

Anti-fibrosclerotic effects of shock wave therapy in lipedema and cellulite

Response of Post-Mastectomy Lymphedema to Extracorporeal Shockwave Therapy

The Physics of Shock Wave Lithotripsy

EPAT Therapy Side Effects & Contraindications

Shockwave Therapy for Acute vs Chronic Wound Treatment

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Evaluation of the LithoGold LG-380 lithotripter: in vitro acoustic characterization and assessment of renal injury in the pig model

Evidence supporting extracorporeal shockwave therapy for acute and chronic soft tissue wounds

Low-Energy Extracorporeal Shock Wave Ameliorates Streptozotocin Induced Diabetes and Promotes Pancreatic Beta Cells Regeneration in a Rat Model

Antimicrobial peptide LL37/RNA complexes stimulate Toll-like receptor 3 upon shock wave therapy

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Biologic Response

The link between shockwaves and innate immunity – the main working mechanism?

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LL37 and shock waves

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IVSWT Water Bath V2.0: Standardized model for in-vitro shock wave treatment (IVSWT)

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Biological Principles – Mechanotransduction

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Biological mechanism of musculoskeletal shockwaves

Shock waves are defined as types of acoustic pressure waves that develop during sudden releases...
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​The biologic effects of SoftWaves and rationale for spine and brain therapy

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IVSWT Water Bath V2.0 Manual

The number of in-vitro experiments in shock wave science increases continuously. This fact reflects how...
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​Low-energy shock wave for enhancing recruitment of endothelial progenitor cells: a new modality to increase efficacy of cell therapy in chronic hind limb ischemia

Stem and progenitor cell therapy is a novel approach to improve neovascularization and function of...
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Shock wave application to cell cultures

Shock waves nowadays are well known for their regenerative effects. Basic research findings showed that...
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Shockwave treatment enhances cell proliferation and improves wound healing

Shock wave treatment accelerates impaired wound healing in diverse clinical situations. However, the mechanisms underlying...
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Shock wave as biological therapeutic tool: from mechanical stimulation to recovery and healing, through mechanotransduction

Extracorporeal Shock Wave Therapy (ESWT) is a form of “mechanotherapy”, that, from its original applications...
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Latest Basic Research Abstracts

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Lohse – Busch ISMST Presentation

High-energy ESW can destroy non myelinated nerves but afterwards there is an even faster regeneration....
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Effect of shock waves on macrophages

Extracorporeal Shock Wave Therapy (ESWT) is broadly used as a non-surgical therapy in various diseases...
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Shockwaves prevent from heart failure after acute myocardial ischemia via RNA/protein complexes

Shock wave treatment (SWT) was shown to induce regeneration of ischaemic myocardium via Toll-like receptor 3 (TLR3)....
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Focused high‐energy extracorporeal shockwaves as supplemental treatment in a rabbit model of fracture‐related infection

Focused high‐energy extracorporeal shockwave therapy (fhESWT) is used to improve fracture healing in cases of...
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Toll-like receptor 3 signalling mediates angiogenic response upon shock wave treatment of ischaemic muscle

Shock wave therapy (SWT) represents a clinically widely used angiogenic and thus regenerative approach for...
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Shockwave therapy differentially stimulates endothelial cells: implications on the control of inflammation via toll-like receptor 3

(Johannes Holfeld, Can Tepeköylü, Radoslaw Kozaryn, Anja Urbschat, Kai Zacharowski, Michael Grimm, and Patrick Paulus)...
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Low energy shock wave therapy induces angiogenesis in acute hind-limb ischemia via VEGF receptor 2 phosphorylation

(​University Hospital for Cardiac Surgery, Innsbruck Medical University, Innsbruck, Austria, 2 Division of Clinical and...
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